Ovarian Rejuvenation with PRP
For years women with Poor Ovarian Reserve or those with Ovarian Failure have had only one option to conceive that is IVF with Egg Donation. Care IVF has developed a program to manage this through:
- Nutritive Therapy
- Alternative Medicine
- Intra-Ovarian Infusion of PRP
Care IVF is probably the First IVF Center in India to include PRP therapy for management of Poor Ovarian Reserve. For those considering EGG Donation, Care IVF’s PRP for Ovarian Rejuvenation Therapy may be worth a try.
PRP therapy offers menopausal women and those with poor ovarian reserve or ovarian dysfunction, a chance to conceive using their own eggs. If injected into tissue, growth factors in plate rich plasma can induce stem cells in that damaged area to regenerate into the tissue specific cells thereby healing the damage. Platelet rich plasma injection into ovaries can thus help revive their ability to produce eggs in women with Primary Ovarian Insufficiency and Poor Ovarian reserve.
Restoring the Ovarian Function
Menopause occurs when the egg cells in ovaries have declined. Which means women have no more egg cells to form eggs. Scientists have been aware of the ability of Stem cells to develop into any type of cell in the presence of growth factors. This opens up the possibility of stimulating stem cells within the ovaries to convert into egg cells thereby restoring the egg laying function of the ovaries. The growth factors are derived from the woman’s own blood. The wound healing property of blood comes from its Plasma component which is rich in platelets that secrete growth factors required for wound healing. PRP Therapy for Ovarian rejuvenation aims at extracting this Platelet rich plasma from the blood sample taken from the woman and injecting the same into the woman’s ovaries. This experimental PRP therapy has shown positive results in women in menopause and has helped them conceive after menopause using their own eggs.
What is the role of Growth factors in rejuvenation?
Growth factors are secreted naturally by many class in the body. Growth factors primary role is to
trigger cell division and is responsible for formation of new cells, growth of tissues, muscles, bones,
organs and perhaps most importantly wound healing.
The Platelets in the plasma component of blood secrete several such growth factors that induce wound healing by formation of new skin, blood vessels, tissues, new nerve endings. This wound healing and regenerative capability of PRP has been exploited for years to accelerate healing in sports injuries. The same can also help in restoring function in ovaries and help form new egg precursor cells. PRP extract has a number of growth factors that can help in ovarian regeneration and restore normal function in ovaries.
- platelet-derived growth factor (PDGF)
- Transforming growth factor (TGF), platelet factor interleukin (IL)
- Platelet-derived angiogenesis factor (PDAF)
- Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF)
- Insulin-like growth factor IGF and Fibronectin.
Is PRP therapy for ovarian rejuvenation effective?
So far PRP therapy has given successful results worldwide and has helped menopausal women conceive naturally using their own eggs. We have achieved significant success for couples who have used this therapy at Care IVF and have been able to conceive successfully.
How is ovarian rejuvenation with PRP performed?
The procedure takes place in two steps. First several tubes of blood is extracted from your body using
injection. The Blood sample in then processed to separate the Platelet rich plasma component from the
White blood cells and Red blood cells.
The second step involves injection of this PRP into the ovaries in a procedure quite similar to Egg Pick up. The PRP Therapy is minimally invasive. Local anaesthesia is provided in order to ensure that you don’t feel any pain during the procedure. The whole process takes a 2-3 hours.
How is PRP sample prepared?
PRP is extracted using a specially designed centrifuge machine and a special conical tube. About 15 ml of blood is taken from the patient, injected into the conical tube and centrifuged. What we get is red blood cells at the bottom of the tube and a buffy coat above. To get a superior yield of PRP, this buffy coat must be processed again to get almost 8x concentration of Platelets along with growth factors. The sample must be used immediately. Sometimes particular cases require activation of platelets outside the body and for this some chemicals need to be added to the PRP sample. The PRP preparation takes about one hour. the PRP sample. The PRP preparation takes about one hour.
How is PRP infusion done?
Just after periods finish and before the follicles start to grow, the patient is called empty
stomach to the clinic. Blood is taken and PRP prepared. Under light sedation (same as used for
IVF egg collection) and under ultrasound guidance, the prepared sample is injected into both
ovaries. The process takes roughly 2 mins and the patient can go home in an hour. This process is repeated once every month for a total of 3 times.
Who can go for ovarian rejuvenation with PRP therapy?
Encouraging PRP results in experimental trials has opened up a potential window for treating a variety of problems in women. Women with following conditions can give it a try:
- Primary ovarian Insufficiency
- Advanced maternal age
- Poor Ovarian reserve
- Loss of ovarian function due to chemotherapy
- Ovarian dysfunction